So, to wrap up this thread, here are the 5 handguns that I ended up purchasing with my 5 permits (yeah, I guess I have a thing for Rugers):
- Ruger LCR; 38 special. Purpose: at-home carry; maybe would be a warm weather concealed carry option when/if I move to a state that respects the 2nd Amendment.
- Ruger GP100; 357/38 special. Purpose: nightstand, bump-in-the-night gun -- I wanted a revolver because I had concerns about my ability to operate a semi-automatic pistol if woken up from a deep sleep at 3 a.m. needing to defense my family; also would be the gun I hand to a novice family member or trusted friend I needed to arm in a SHTF situation.
- Ruger GP100; 22LR. Purpose: this was an unexpected purchase, but I enjoyed shooting the revolvers so much that I decided to pick up a 22LR revolver for training / target shooting; also, eventually this will be the gun that I use to teach my wife how to shoot, and it *may* end up being her go-to home defense gun (yes, it's not ideal, but if she's not comfortable with a larger caliber, it's better than a knife).
- Glock 19 Gen4; 9mm. Purpose: this gun is going to mainly be used only at the range for now; I suspect that this will become my primary carry firearm once that right is available to me.
- Ruger 22/45 Mark III. Purpose: this was just a "fun" purchase for the most part, that in retrospect I don't really "need"; I picked this up before I decided to get the GP100 22LR, thinking it would be my only 22LR; I will use it for target practice at the range, and in the back of my head I have dreams of one day tricking it out with a suppressor and using it to dispatch varmints on my little plot o'land out in the country.

So . . . good, bad, or ugly, that's where I ended up.
Thanks to everyone who offered their opinions and advice - I really appreciated it!