Construction lumber is not kiln-dried enough to eliminate all shrinkage and twisting, so if the drawers are going into a cabinet allow for that. The more weight of course will require higher load bearing drawer slides, which can dramatically increase the cost. The post title calls for "weight saving" but now you mention you want weight, so please clarify.
1/2" birch, or marine, ply is strong, but can get very expensive and might be overkill for a bottom. You'd be surprised, if you don't know it already, that there is a 1/4" ply that is used for floor underlayment that is light and extremely resilient. A very strong drawer for tools can be built using that for the bottom and 1/2" ply for the sides. But I would dado the drawer sides & front/back 1/2" from the bottom, 1/4" deep and glue and nail (staple nail) 1/2" x 2" wide ply slats horizontally to the sides under the bottom at the ends and middle. If you use drawer slides, with the drawer construction mentioned, or any for that matter, take note of where the screw holes for the slides will need to be on the drawer sides as you do not want them to be at the same location as the dado on the other side.